Tripit
This web site brings back the old days when you can just leave all the work up to your travel agent. Times Online’s review says:
The site brings together flight, hotel and car rental bookings to supply a single itinerary, and adds information such as daily weather forecasts, local maps, city guides and updates from other useful travel websites.
These include Seatguru, for its advice on getting the best spot on the aircraft, Flickr, for its travel photos so you can get a sneak preview of where you’re going, or find photos you’d like to take yourself, and Eventful, to see what’s going on in your chosen destination.
The only thing is that this site is a bit biased towards the US – it may not recognize some European airlines. I am sure that they will be updating and upgrading their services pretty soon.
Travelsupermarket
To offset the US bias of Tripit, you may want to visit Travelsupermarket instead. They have an extensive database of hotels and even B&Bs in the UK. I like how easy it is to search for a place to stay. The downside is that Travelsupermarket is not a direct booking site. That is, if you want to book your accommodations, you will be redirected to another site which will do the booking for you. When you think about it, though, it’s not such a big hassle. Another thing is that you will not find a lot of information by way of user reviews – yet. I am sure that this area will grow soon enough.